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As an editorial and comic cartoonist, Les Golden has been widely published. His subjects are taken from his interest in politics and other careers as a stand-up comedian, actor, writer, musician, environmentalist, animal welfare advocate, astronomer, and professor. He may be best known for his strip "Captain Industry" from the 1980's. His content ranges from politically controversial to school-boy silliness, with a clean line-art artistic style. His textbook, Laboratory Exercises in Physics for Modern Astronomy (Springer-Verlag, 2012), includes numerous of his comic illustrations, including those of possible extraterrestrials. He credits Betty Edwards, author of Drawing On the Right Side of the Brain, as his major artistic influence.